Thursday, October 31, 2013

Diabetic Women at Higher Risk of Heart Disease

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Diabetic Women at Higher Risk of Heart Disease
Nov 1st 2013, 06:39


Lead study author Rita Rastogi Kalyani, M.D., M.H.S., endocrinologist at the Johns Hopkins University School of Medicine, said that their findings suggest that we need to work harder to prevent heart disease in women under 60 who have diabetes.

She said that this study tells us that women of any age who have diabetes are at a high risk for coronary artery disease.

For the research, she and her colleagues analyzed data from more than 10,000 participants in three widely regarded studies: the GeneSTAR Research Program, the Multi-Ethnic Study of Atherosclerosis and the National Health and Nutrition Examination Survey (NHANES) III.

None of the participants had a history of heart disease. All three studies yielded similar gender differences in rates of diabetes and the risk of developing heart disease.

Interestingly, in both women and men, these findings were unrelated to differences in obesity and other traditional cardiovascular risk factors such as high blood pressure, cholesterol and smoking.

The study has been published in the journal Diabetes Care.

Source-ANI

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Thyroid Levels may be Linked to Survival Rate in Hospitalized Patients

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Thyroid Levels may be Linked to Survival Rate in Hospitalized Patients
Nov 1st 2013, 06:39

Low levels of thyroid may increase the risk of death in hospitalized patients, says study published in Journal of Clinical Endocrinology & Metabolism (JCEM).

 Thyroid Levels may be Linked to Survival Rate in Hospitalized Patients


The thyroid gland, located in the neck, produces hormones that regulate the body's temperature, consumption of oxygen and metabolism. The gland produces two hormones, triiodothyronine (T3) and thyroxine (T4), which travel through the blood to spur activity in various tissues.

"When older individuals have low levels of thyroid hormones, particularly T3, it reflects that the body is weak and more susceptible to the harmful effects of disease," said the study's first author Pedro Iglesias, MD, of Hospital Ram�n y Cajal in Madrid, Spain. "As a result, older individuals who have a reduced ability to synthesize T3 hormones have a higher rate of mortality, both in the short- and long-term."

As part of the prospective observational study, researchers measured thyroid hormone levels in all patients who were 65 years of age or older when they were admitted to the Hospital General in Segovia, Spain in 2005. For 404 patients, researchers tracked the length of hospital stay and the survival rate among the group as of Jan. 1, 2012.

During the seven-year study, 323 patients died. The study found an association between low levels of thyroid hormones and mortality. The analysis found low levels of thyroid hormone, in particular T3, tended to be a predictor for all-cause mortality. The patients in the group with the lowest levels of T3 hormones and thyroid-stimulating hormone, which the body uses to activate the thyroid gland, also had higher rates of death from cardiovascular disease.

"T3 could be a useful measure for gauging an older individual's chances of surviving an acute illness requiring hospitalization," Iglesias said. "The reduced ability to synthesize the hormone observed in this group of patients could be related to the severity of the disease and its prognosis."

Source-Eurekalert

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Stress Eaters may Compensate by Eating Less: Study

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Stress Eaters may Compensate by Eating Less: Study
Nov 1st 2013, 05:37


The study, published in Psychological Science, a journal of the Association for Psychological Science, shows that "munchers" and "skippers" display compensatory patterns of consumption in response to positive and negative social situations. While munchers in the study ate more after being stressed, they ate less in response to a positive situation; skippers actually showed the reverse pattern, eating more after a positive experience.

"These findings challenge the simplistic view that stress eaters need to regulate their eating behavior to prevent weight gain," says lead researcher Gudrun Sproesser of the University of Konstanz, in Germany. "Both skippers and munchers have their 'soft spot' for food, they just show different compensatory eating patterns in response to positive and negative situations."

Sproesser and colleagues recruited volunteers to participate in a study on "first impressions." The participants interacted with an unfamiliar partner by video before meeting them in person. After making their own videos, the participants received one of three messages in return: Some heard that their partner had decided not to meet with them after seeing the video, while others heard that their partner liked them and looked forward to meeting them. A third control group was told that the experiment had to be cancelled for other reasons.

Then, the participants went on to participate in a supposedly unrelated study involving a taste test for three flavors of ice cream. They were allowed to eat as much ice cream as they wanted.

The results showed that, when faced with negative feedback, self-identified munchers ate more ice cream than participants in the control group, while self-identified skippers ate less. Munchers ate, on average, about 120 more calories' worth of ice cream than did the skippers.

But, when faced with positive feedback, munchers actually ate less than the control group, while skippers tended to eat more � the skippers consumed, on average, 74 calories' worth more than the munchers.

"We predicted that munchers and skippers differ in food intake after experiencing a positive situation," says Sproesser. "However, we were rather surprised that the data showed an almost mirror image in ice cream consumption when compared to the data from the social exclusion condition."

The research offers insight for anyone who wants to understand the relationship between stress and eating, but it has specific importance for clinicians and practitioners working to promote healthy eating.The patterns of calorie consumption suggest that the behavior of both munchers and skippers could significantly influence body weight over time.

"Stress eaters should not be considered at risk to gain weight by default," says Sproesser. "Our results suggest the need for a dynamic view of food intake across multiple situations, positive and negative."

"Furthermore, our findings suggest rethinking the recommendation to regulate stress eating. Skipping food when being stressed may cause additional stress in munchers and could possibly disturb compensation across situations."

Source-Eurekalert

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Enterocystoplasty is Safe and Effective For Children With Genitourinary Abnormalities

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Enterocystoplasty is Safe and Effective For Children With Genitourinary Abnormalities
Nov 1st 2013, 05:37


Enterocystoplasty is a surgical enlargement of the urinary bladder which is performed to improve bladder function as a low-pressure reservoir.

"This issue is very important because in children this surgical procedure is very aggressive and we must understand the major factors that can determine its long-term success in order to provide the best quality of life to the patients," according to Dr. F�bio A. Esc�rcio de Almeida, who presented the results of this study at the recent 2nd Joint meeting of ESFFU, ESGURS and ESOU (EAU Section of Functional Urology, EAU Section of Genitourinary Reconstructive Surgeons and the EAU Section of Oncological Urology).

"This research improves our knowledge on the best surgical techniques for selected patients. If we prove that this kind of technical variation will improve the functional long-term outcomes, then we could do this kind of procedure with a greater confidence of better results in the future," he explained.

In the course of the study, epidemiological and clinical data were collected from our prospective database of all patients under 18 years old submitted to enterocystoplasty, between January of 1996 and December of 2011. Twenty five patients were submitted to enterocystoplasty (15 male). Twenty percent had an non neurogenic dysfunction (5 bladder exstrophy). Thirteen children (52 %) had vesicoureteral reflux (VUR) pre-operativelly. Four patients had chronic renal failure in hemodialysis in pre-transplant preparation. Radiological and urodynamic investigation was performed preoperatively and postoperatively.

In evaluating the procedure within the framework of this study, which involved a median follow-up period of 8 years, the authors recorded several instances of complications. Four patients developed vesico-cutaneous fistula that required open surgical management and one patient developed bladder lithiasis that was submitted to an endoscopic approach. At cut-off point, all patients were continent and 24 patients performed clean intermittent self-catheterisation.

"This research is the first step because in our effort to understand if this technical variation can improve the patients' outcomes. In the futre, we have to compare this cohort of patients with another in which a different surgical techinique was uses," summed up the lead author of the study. "Currently, we are preparing data to initiate such a study."

Source-Eurekalert

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Studies Find U.S Military Veterans Smoke Way More Than Civilians

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Studies Find U.S Military Veterans Smoke Way More Than Civilians
Nov 1st 2013, 05:37


"The military, which is its own subculture, still has one of the highest rates of tobacco use of any occupational group, both smoking and smokeless," said lead study author Walker S. Carlos Poston, Ph.D., M.P.H. at the Institute for Biobehavioral Health Research of the National Development and Research Institutes, Inc.

Veterans service organizations (VSO) should provide more online support for smoking cessation, the authors said, because "veterans who smoke are less likely to quit, they have been specifically targeted by the tobacco industry, and there is evidence that the military still provides a supportive atmosphere for tobacco use and initiation, such as substantially discounted cigarettes for active military and eligible veterans and retirees and the lack of consistent tobacco control policy enforcement."

Researchers evaluated websites for veteran service organizations such as the American Legion, Disabled American Veterans and Veterans of Foreign Wars, all of which differ substantially in the range of veterans they serve. They found 277 health topics addressed on 24 websites, the top five of which were insurance issues, post traumatic stress disorder (PTSD), disability and amputation, Agent Orange, and traumatic brain injury.

"Tobacco-related content was virtually nonexistent," they said. Tobacco was mentioned only 4 times across all 24 websites and smoking cessation was never mentioned.

Tobacco use impacts active military and veterans with smoke-related illnesses like pulmonary and cardiovascular diseases and cancer, and worsens PTSD symptoms. It also negatively impacts family members-due to increased health care costs and caregiver burdens.

The military does offer a free state-of-the-art "quit smoking" program, and a telephone quit line for active duty and veterans, Poston said. "That's good, since smoking costs the military a lot more than other habits, including overeating and resulting problems of overweight and obesity."

The authors suggested a number of concrete ideas to increase VSO awareness and engagement around the topic of tobacco use. For example, providing VSOs with training for smoking cessation peer interventionists for prospective quitters and encouraging VSOs to include smoking cessation materials on their Web sites and provide links to the respective state quit telephone lines and other public domain smoking cessations resources, including the American Lung Association, the American Heart Association, the National Institutes of Health and the American Legacy Foundation.

"I can't say I'm shocked by the findings. It was both impressive and depressing how little mention there was of tobacco use or smoking cessation on the websites," said Harry A. Lando Ph.D., a professor at the University of Minnesota's School of Public Health''s Division of Epidemiology and Community Health. "But I would have thought there'd be at least more mention of tobacco on the websites."

The military can be a breeding ground for taking up smoking, he said. "It seems it would be very low cost to implement some of the recommendations the authors made, to put some of that information on websites about quitting, or to include other resources."

Source-Newswise

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For Recipients "Fresher" Blood Donations May Be Better

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For Recipients "Fresher" Blood Donations May Be Better
Nov 1st 2013, 05:37


Duration of storage is dependent on a number of factors, including the management system, supply and demand, and blood type (less common blood types, such as Type AB negative, tend to be stored longer than more common types, particularly Type O). Currently, the Food and Drug Administration (FDA) limits storage duration to a maximum of 42 days, depending on the storage system.

"Stored blood undergoes changes, meaning that transfusion of older red blood cells may result in the delivery of high concentrations of red blood cell components such as hemoglobin, free iron, and red blood cell fragments," said Colleen G. Koch, MD, MS, MBA, from the Cleveland Clinic in Ohio. "These components may contribute to adverse clinical events observed in a number of investigations."

Dr. Koch and colleagues reviewed existing literature to examine the presence of storage-related complications in patients who underwent blood transfusions. They found several studies in trauma and cardiac surgery that linked increased blood storage duration to post-injury multiple organ failure, infection, deep vein thrombosis, and hospital mortality, while other studies reported no apparent relationship between storage duration and clinical outcomes.

Several ongoing randomized controlled trials may answer more questions in the future. Meanwhile, the researchers recommend exploring changes to the current first-in, first-out process. They pointed to new models of inventory management in the retail sector that would reduce inventory shelf time in favor of just-in-time delivery of products.

"We hope our results engage others in the medical community to investigate alternative inventory management strategies that would contribute to reducing the storage age of the red cell product without adversely influencing inventory availability," said Dr. Koch.

One existing model involves blood platelet donation. Platelets expire 5 days after donation, so managing platelet inventory requires hourly monitoring and more frequent deliveries from blood collection agencies. Using these same techniques for red blood cell donations could help reduce blood storage duration to 14 days or less, according to the researchers.

"We recommend further work with inventory management to explore strategies that would optimize fresher blood for patients," said Dr. Koch. "Until results of ongoing randomized controlled trials in the area of storage duration are completed, we cannot recommend a change in the current FDA formal guidelines; however, we encourage surgeons to remain aware of the possible complications associated with red blood cell transfusion."

Source-Newswise

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New York City Bans Sale of Cigarettes, Tobacco and E-Cigarettes to Under 21s

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New York City Bans Sale of Cigarettes, Tobacco and E-Cigarettes to Under 21s
Oct 31st 2013, 20:33

New York City voted to ban the sale of tobacco, cigarettes and e-cigarettes to people under the age of 21, raising the previous threshold of 18.

New York is the first large city to raise the age limit so high, a resolution that follows years of increasingly stringent laws on tobacco.


The federal age requirement for buying cigarettes is 18, which some states previously raised to 19.

A spokeswoman for New York City council said the proposal was approved by 35 votes to 10.

New York was the pioneer of a ban on smoking in bars, restaurants and public places -- initially criticised -- but since adopted in cities across the West.

Cigarette taxes are also the highest in the US.

Authorities hope that raising the legal age for buying cigarettes will reduce the number of smokers aged 18-20 by 55 percent.

But the move will be unpopular among those who feel that outgoing Mayor Michael Bloomberg has already over-stepped the line between protecting public health and interfering with personal choice.

City hall has said that in 10 years the percentage of adults who smoke has fallen from 21.5 percent in 2002 to 14.8 percent in 2011.

Among young people it has remained unchanged since 2007, at 8.5 percent according to official statistics.

Source-AFP

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Scientists Are Exploring Whether Malignant Neural Stem Cells Give Rise To Brain Tumor Stem Cells

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Scientists Are Exploring Whether Malignant Neural Stem Cells Give Rise To Brain Tumor Stem Cells
Oct 31st 2013, 20:33

It is believed that glioma is derived from brain tumor stem cells. Despite this, the source and molecular signal pathways of these cells are still unclear.

 Scientists Are Exploring Whether Malignant Neural Stem Cells Give Rise To Brain Tumor Stem Cells


The potential of neural stem cells to transform into brain tumor stem cells has long been considered, but has not been confirmed. A team led by Prof. Yingbin Li from the Second Affiliated Hospital of Nanjing Medical University, China found that doxycycline-induced neural stem cells in the subventricular zone of c-myc+/SV40Tag+/Tet-on+ transgenic mice have increased proliferative activity and inhibitory differentiation similar to tumor stem cells, suggesting that neural stem cells have a tendency for malignant transformation, and could be a source of tumor stem cells. These findings were published in the Neural Regeneration Research (Vol. 8, No. 25, 2013).</<br>
Source-Eurekalert

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Early Medication of HIV is Cost-Effective: Study

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Early Medication of HIV is Cost-Effective: Study
Oct 31st 2013, 20:33


The study in the New England Journal of Medicine analyzed the economics of giving antiretroviral drugs to people with HIV before their viral load gets too high.

While researchers have already determined that early treatment has many health benefits, its cost -- about $23,000 a year according to the US Centers for Disease Control and Prevention -- has remained a concern for considering widespread early treatment in low and middle income countries.

By projecting the treatment costs over time and accounting for the effects of better health and fewer infections, researchers found long-term economic benefits in both countries.

"In short, early ART is a 'triple winner': HIV-infected patients live healthier lives, their partners are protected from HIV, and the investment is superb," said co-author Rochelle Walensky of the Massachusetts General Hospital.

"This study provides a critical answer to an urgent policy question."

Researchers chose to focus on South Africa and India because they had the highest numbers of people with HIV among nine countries studied in a clinical trial known as HIV Prevention Trials Network (HPTN) 052.

The trial showed that treatment as prevention dramatically reduced the risks of viral transmission and also substantially cut back the development of infections like tuberculosis in the HIV-infected patients.

South Africa and India were also representative, respectively, of the middle and lower income countries where these questions persist over how early to treat people for HIV.

Early ART was defined as therapy initiated when the CD4+ T-cell count ranged from 350 to 550 per cubic millimeter, and delayed ART as therapy initiated when the CD4+ count was below 250 per cubic millimeter.

"We found that early ART substantially improved the rate of survival of infected patients, greatly decreased the rate of early HIV transmissions, and provided an excellent return on investment," said the study.

For the first five years, the results showed that 93 percent of patients receiving early ART would survive, compared with 83 percent of those whose treatment was delayed.

Life expectancy for the early-treatment group was longer too -- almost 16 years, compared with nearly 14 years for the delayed treatment group.

"Now that we know that early ART not only improves clinical and prevention outcomes but also is a great investment, we need to redouble international efforts to provide ART to any HIV-infected person who can benefit from it," said Walensky.

Source-AFP

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A New Protein Fold Was Discovered With a Transport Tunnel By Scientists

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A New Protein Fold Was Discovered With a Transport Tunnel By Scientists
Oct 31st 2013, 20:33

The protein LIMP-2 is vital for both humans and animals. If it is absent substances of an unknown nature, probably lipids, accumulate in the organism.

Up to now, scientists were unsure what the protein looks like and how exactly it functions. Privatdozent [senior lecturer] Dr. Michael Schwake from the Faculty of Chemistry at Bielefeld University (Germany) is doing research on the protein - and thereby preparing the way for future therapies. Together with colleagues in Kiel, Toronto, and Boston, he has now discovered that the protein LIMP 2 possesses a novel protein fold together with a nanomicroscopically small transport tunnel. The researchers have published their findings on Sunday (27 October) in the globally renowned scientific journal Nature.

Proteins are composed of amino acids. Although these are lined up as if along a string, they produce a twisted three-dimensional structure of helices and sheets. It is only this pleating that enables them to influence biological cells. 'We are decoding the structure and function of proteins in order to find out how biochemical processes within them take place,' says Schwake.

To study LIMP-2, Schwake's colleagues from the Canadian University of Toronto have crystallized the protein. Then they can use X-ray diffraction analysis to ascertain its crystalline structure. 'When analysing the images, we detected a protein fold that has not been described in any other protein up to now,' says Schwake.

Source-Eurekalert

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Child Gun Shot Wounds Linked To Prevalence of Household Gun Ownership

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Child Gun Shot Wounds Linked To Prevalence of Household Gun Ownership
Oct 31st 2013, 20:33

Due to injuries sustained from guns, there are approximately 7,500 child hospitalizations and 500 in-hospital deaths each year. In an abstract presented Oct. 27 at the American Academy of Pediatrics (AAP) National Conference and Exhibition in Orlando, researchers also identified a link between the percentage of homes with guns and the prevalence of child gunshot injuries.

In "United States Gunshot Violence�Disturbing Trends," researchers reviewed statistics from the Kids' Inpatient Database (KID) from 1997, 2000, 2003, 2006 and 2009 (for a total of 36 million pediatric hospital admissions), and estimated state household gun ownership using the most recent Behavioral Risk Factor Surveillance System data (2004).

The study found that approximately 7,500 children are admitted to the hospital for the treatment of injuries sustained from guns each year, and more than 500 children die during hospital admission from these injuries. Between 1997 and 2009, hospitalizations from gunshot wounds increased from 4,270 to 7,730, and in-hospital deaths from 317 to 503.

The study also found a significant association between the percentage of gunshot wounds occurring in the home and the percentage of households containing any firearms, loaded firearms and unlocked loaded firearms.

"Handguns account for the majority of childhood gunshot wounds and this number appears to be increasing over the last decade," said lead study author Arin L. Madenci, MD, MPH. "Furthermore, states with higher percentages of household firearm ownership also tended to have higher proportions of childhood gunshot wounds, especially those occurring in the home."

Many current gun control efforts focus on limiting the availability of military-style semi-automatic assault rifles.

"Policies designed to reduce the number of household firearms, especially handguns, may more effectively reduce the number of gunshot injuries in children," said Dr. Madenci.

Source-Eurekalert

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Parenting Classes Starts in France

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Parenting Classes Starts in France
Oct 31st 2013, 20:33


French parents today want a new kind of authority that does not crush children but does not allow them to run wild either, said Beatrice Sabate, a clinical psychologist who adapted a method devised in California called "positive discipline" for France.

"There are rules, but the child helps to define them," said Sabate.

"Children are growing up in a different world than that of their parents," when teachers were more severe and adults always knew best.

Today "parents are looking to have relationships that are based more on cooperation," she said.

In one class, nine mothers and three fathers meet in central Paris one evening a week, sitting in a circle with two trainers to learn "positive discipline", which combines firmness with an emphasis on the positive.

Slogans on the wall intone: "Encouragement is to the child as water is to a plant" and "Mistakes are excellent learning opportunities."

This session is devoted to "inappropriate behaviour", with participants role-playing some of the most common sources of conflict: homework, computer and television time, going out.

"OK, it's your turn. You're a child again," says trainer Alix de Salaberry, to a participant playing the role of a teenage girl who wants to sleep over with a friend.

The "mother" says no and the "daughter" stamps her foot, shouting, "I hate you!"

"What do you feel?" De Salaberry asks the "mother" who replies: "She scares me. I'm not going to manage."

The role play starts again, but this time the "mother" has to give an "appropriate response".

So she offers: "I'm really glad you have such good friends. Like you, when my mother said no, I was very disappointed. But it's not possible tonight, your grandmother is coming for dinner. Let's find another date."

'Parents don't trust themselves'

At the end of the session, the students are given homework: "Role-play with your child. You be the child and your child can be the adult."

"Positive discipline" workshops, originally developed by American family counsellor and educator Jane Nelsen, are growing not just in the capital but elsewhere in France.

Demand has been so great that Sabate no longer teaches classes herself, but devotes her time to training parenting teachers, including students from Belgium, Switzerland and Morocco who train in France then return home to teach "positive discipline" in their own countries.

In France, "views have changed of authority and making mistakes," Sabate told AFP. "Before, children were subordinate to their parents, students to the teacher, the wife to the husband, the worker to the boss."

French education traditionally emphasised the negative: pupils could even get a score below zero on tests. Parents, especially those who have lived in English-speaking countries, try to compensate at home with positive reinforcement.

Alice, 42, said: "Our parents didn't think about what they were doing. I was raised with spankings and lashings with a riding crop. That damages a child. I want to do as little damage to my children as possible. No shouting, no hitting."

The Temp'O Jeunes association specialises in parents of teenagers who are under pressure at school or who are home alone after school or even on their own for several days if a single parent leaves on a business trip.

Among the tools suggested to ensure a "balanced life" for the child is to draw up a schedule that plans out activities down to the half hour: homework, football and violin practice, without forgetting time to read, dawdle or be with friends.

"Parents wonder how to be as effective as possible with the little time they have. They are under pressure from society to succeed in everything," said Emmanuelle Guilhamon, the architect of Temp'O Jeunes.

"Parents don't trust themselves anymore. If they listened to what they have in their hearts or in their gut, they would know how to solve the problems," said Guilhamon, who has four children.

'My mother's a drag'

"The bond with the child has become the most precious in life, because the love bond is fragile, ephemeral," said psychologist Beatrice Copper-Royer. "You expect a lot of it, and many parents are afraid of approaching it badly, of not being up to raising the ideal child that they want."

She added: "The boom in the coaching market reflects the disarray we see in parents. It's very revealing of our society's performance cult. You have to train yourself as much as possible to have the best possible child."

A mother who gave only her first name, Celine, took her seven-year-old son to a number of professionals including a speech therapist to little avail.

But "thanks to 'positive discipline', I put myself in my child's place: 'Brush your teeth, do your homework, hurry up!' ... I thought, 'My mother's a drag'. It was a shock."

Since taking the course, she said: "My son cuddles me all the time. It's magical again to be a parent."

Source-AFP

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