Saturday, November 16, 2013

Drug Trial for Chagas Disease Produces Mixed Results

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Retargeting on Facebook?

Get more sales and conversions with Facebook retargeting. Try it free for 14 days. Set up takes just minutes!
From our sponsors
Drug Trial for Chagas Disease Produces Mixed Results
Nov 16th 2013, 11:09


Less than 1% of patients living with Chagas disease currently receive treatment. The new findings fill a long-standing knowledge gap, providing evidence that will help to inform public health policies and help to increase access to treatment now, as well as shaping the direction of future research for new Chagas therapies.

E1224 is a new antifungal compound discovered and manufactured by the Japanese pharmaceutical company Eisai that is being developed as a treatment for Chagas disease with support from the Wellcome Trust. The Phase 2 double-blind, randomized, controlled trial evaluated the safety and efficacy of E1224 at three different dose regimens and was the first study to collect comprehensive clinical data on the current approach to treatment, benznidazole. Both treatments were compared to a placebo control.

A total of 231 adult patients with chronic indeterminate (showing no symptoms) Chagas disease were treated for a maximum of 60 days and evaluated at treatment completion and at several different time points up to a 12-month follow-up assessment. The study took place at two sites (Cochabamba and Tarija) in Bolivia, which have the world's highest incidence of Chagas disease.

At end of treatment, E1224 was found to be safe and efficacious in clearing the Chagas parasite in patients when compared to placebo and to benznidazole. Few patients receiving the highest dose stopped treatment with E1224 due to side effects, less than in the benznidazole group. However, at 12 months after treatment, less than one third of patients treated with E1224 continued to maintain parasite clearance compared with over 80% of patients treated with benznidazole, demonstrating relatively low sustained eradication rates with E1224 in this study.

"In this prospective placebo-controlled study, these mixed results actually have provided very important scientific evidence on new drug development for Chagas disease, which has long been ignored," said Dr Isabela Ribeiro, Head of the Chagas Clinical Programme at DNDi, and the E1224 Project Leader. "We now have clear safety and efficacy data on two compounds that will be very useful in guiding future Chagas disease drug research efforts."

Although E1224 was found to be ineffective as a single-treatment agent (monotherapy), it holds promise for use in combination with existing drugs, since it showed strong positive activity during treatment, with a third of patients having a sustained treatment response at the higher dose. E1224 will no longer be tested as monotherapy for Chagas disease, but DNDi and Eisai are exploring the possibility of testing E1224 in combination therapy with benznidazole

"Eisai remains committed towards the elimination of neglected tropical diseases and hopes to continue collaboration with DNDi in future studies that could determine the role that E1224 may play in the treatment of chronic indeterminate Chagas disease and provide newer and better treatment options for patients suffering from this disease," stated Dr Frederick P. Duncanson, Senior Director of Chief Innovation Officer Group at Eisai Inc., and the E1224 Project Leader at Eisai.

In addition to evaluating E1224, the study was the first to compare the clearance of Chagas parasites (Trypanosoma cruzi) with benznidazole treatment versus placebo in adults with chronic indeterminate Chagas disease. Benznidazole had a rapid and sustained effect, with significant drop in parasite counts after just one week of treatment. Some patients experienced adverse events, mostly nausea, skin reactions, and muscle and nerve pain. Since benznidazole treatment is typically 60 days long and undesirable side effects are common, shorter courses of the drug may be safer yet still effective. Based on these study findings, DNDi will investigate shorter-course treatments with benznidazole.

The study was the first Phase 2 clinical trial conducted in Bolivia, exemplifying the strengthening and sustaining of research capacity in a resource-limited, developing-country setting. A total of 97% of the enrolled patients completed follow-up at 12 months post-treatment, with only 7 of the 231 patients being lost to follow-up. Important Chagas patient data were collected on pharmacokinetics and pharmacodynamics, characterization of the parasite population before and after treatment, and candidate biological markers for evaluation of treatment response.

"The completion of this drug trial was a success story for Chagas patients, doctors, and researchers in Bolivia, demonstrating that excellent clinical testing can be carried out in endemic countries," said Dr Faustino Torrico of Universidad Mayor de San Simon in Cochabamba, Bolivia, and one of the lead investigators. "The data generated were of high quality, and our clinical sites and research teams gained valuable experience and are ready to perform future studies."

"Chagas disease is one of world's most neglected illnesses, and millions of patients continue to be ignored and many needlessly die from the lack of treatment access and options," said Dr Bernard P�coul, Executive Director of DNDi. "We have to take advantage of these important study results to scale up treatment access now, while we maintain momentum in developing safer, more effective, life-saving new treatments for Chagas patients around the world."

Source: Eurekalert

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Colombia's Cali Home to a Very Unique 'Hotel'

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Retargeting on Facebook?

Get more sales and conversions with Facebook retargeting. Try it free for 14 days. Set up takes just minutes!
From our sponsors
Colombia's Cali Home to a Very Unique 'Hotel'
Nov 16th 2013, 11:09


Working in a posh neighborhood of Cali, Colombia's third largest city, the 55-year-old Diaz pampers her clients, from the time they get off the plane throughout their stay at her clinic.

She looks over them during their post-surgical convalescence, treating them to special diets and massages. A bilingual nurse who speaks English helps out.

"The most important thing is love, affection. We are here to give a little of it to people who need it while they have left their family, their husband, their children, who are also suffering for them on the other side of the world," she told AFP. Many patients get depressed after surgery, she says.

Her calling started off in a personal way. Her daughter, living in the United States, came home for a tummy tuck with liposuction. Mom's tender loving care prompted her to suggest Diaz open up the beauty-oriented hotel.

It now has a dozen rooms, with prices ranging from $55 to $68 a day.

Business is good because Colombia has a tradition as being a good place for plastic surgery. It is the third busiest in the sector in Latin America, after Brazil and Mexico, and ranked 11th in the world.

Every year more than 200,000 plastic surgery operations are carried out in Colombia, or 3.3 percent of the world total, according to the International Society of Aesthetic Plastic Surgery (ISAPS).

One client, a Spanish male nurse aged 39 who asked not to be named, also came for abdominal surgery. He was prompted to do so by a female Colombian friend who talked up Cali. Besides the affordable price, he said, "it is the quality that counts."

Technological Innovation

For Miriam Alvarado, a 53-year-old from Puerto Rico, the decision to undergo surgery in Colombia came after her sister and sister-in-law went under the knife here.

In a matter of two weeks, it was all set: the trip and the operation -- one on her chin, and liposuction.

And oh, what a bargain it was. At home it would have cost her $14,000, but in Cali, it cost less than $4,000.

And the medical facilities seem better to her. "In Puerto Rico there are all kinds of surgeons but the post-op treatment is not as advanced as it is here," Alvarado said.

Another convert is Peter McCabe, a US businessman who lives in Colombia. He had work done on his face, despite warnings from his family not to go through with it.

They said "if you are going to do it, please do it at home," he said.

But after they saw his new face on Skype, many changed their minds and some plan to jump on a plane to Colombia for a bit of tweaking of their own.

But all this is not without risk.

Between three and five percent of patients are not satisfied with the results of their surgery, and that figure jumps to 12 percent for nose work, said Lina Triana, a surgeon in Cali and secretary of ISAPS. She says there are non-qualified people out there offering operations.

But the good ones are in fact really good, she insisted.

"Now it is our colleagues in Europe and the United States who must learn here how to sculpt beautiful bodies," Triana said.

Technological innovation is one of the strong suits of Colombian doctors, who hold a convention every year to show off their techniques.

For instance, Alfonso Riascos unveiled a special method for carrying out a "facial rejuvenation" without leaving telltale scars near the ears, as is often the case.

"I began more or less five years ago with selected patients and now I have 400," he said proudly. A third are foreigners. His trademark is a small and discreet five-centimeter (two-inch) scar on the scalp.

Hotel owner Alba does not expect business to slow down any time soon.

"We have had family groups, with the father, the mother and three children. One of the daughters brought her husband. They love to have company," Diaz said.

Source: AFP

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Democrats Vote for US House Bill Cutting 'Obamacare'

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Microsoft Excel 2010 Training Course

Beginner / Intermediate self-paced online course of Microsoft's spreadsheet application. Enroll for just $99.
From our sponsors
Democrats Vote for US House Bill Cutting 'Obamacare'
Nov 16th 2013, 11:09


But the broad bipartisan vote, even if just a political messaging bill, marked a blow to a president under heavy fire for his largely discredited pledge that all Americans who liked their health plans could keep them.

Added to that is the flawed rollout of the HealthCare.gov website through which millions of Americans are expected to sign up for insurance.

"Today, the House made a big, bipartisan statement about the need to make things right," Speaker John Boehner said in a statement.

"The Keep Your Health Plan Act represents an important step toward providing relief to those who have lost their plans and face much higher premiums, but the real solution is to scrap the president's fundamentally-flawed health care law" altogether, he added.

The controversial measure, which passed 261-157, addresses what has emerged as a major sticking point in the law known as "Obamacare" -- millions being notified that the insurance plans they purchased on the open individual market are being cancelled, apparently because the coverage is sub-standard.

The bill is different from the "fix" proposed by Obama Thursday, which would allow insurers to keep offering such coverage only to those consumers who already are enrolled in the insurance in question.

New consumers would be required to obtain insurance that meets the law's standards. The House measure, however, opens the sub-standard plans to anyone.

Democrat Nick Rahall broke ranks and voted for the bill, saying Americans were disgusted with the "very bad, rotten" rollout of Obamacare.

House and Senate Democrats are offering several fixes of their own, suggesting the unity among Obama and members of his party has begun to fray.

But Rahall downplayed any tension between Obama and congressional members of his party.

"I don't think he should see it as a growing rift between the two but rather as a need to call everybody together to fix the problem," Rahall told reporters.

Senator Mary Landrieu, also a Democrat, is proposing a "permanent" solution that allows consumers with sub-standard plans to keep them for as long as they wish.

But she envisioned that under her bill, those Americans would gradually shift to the more comprehensive plans, whereas the House bill introduced by Republican Fred Upton would essentially kill Obamacare.

House Democratic leader Nancy Pelosi said Upton's bill was a "Trojan horse" that would "essentially pull the plug on the Affordable Care Act."

Source: AFP

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Genes Expressed by the Brain's Immune Cells Identified

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Retargeting on Facebook?

Get more sales and conversions with Facebook retargeting. Try it free for 14 days. Set up takes just minutes!
From our sponsors
Genes Expressed by the Brain's Immune Cells Identified
Nov 16th 2013, 11:09

Investigators have used a new sequencing method to detect a group of genes used by the immune cells of the brain, which sense pathogens, toxins and damaged cells. Identifying these genes should lead to better understanding of the role of microglia both in normal brains and in neurodegenerative disorders and may lead to new ways to protect against the damage caused by conditions like Alzheimer's and Parkinson's diseases. The study, which has been published online in Nature Neuroscience, also finds that the activity of microglia appears to become more protective with aging, as opposed to increasingly toxic, which some previous studies had suggested.

 Genes Expressed by the Brain's Immune Cells Identified


"We've been able to define, for the first time, a set of genes microglia use to sense their environment, which we are calling the microglial sensome," says Joseph El Khoury, MD, of the MGH Center for Immunology and Inflammatory Diseases and Division of Infectious Diseases, senior author of the study. "Identifying these genes will allow us to specifically target them in diseases of the central nervous system by developing ways to upregulate or downregulate their expression."

A type of macrophage, microglia are known to constantly survey their environment in order to sense the presence of infection, inflammation, and injured or dying cells. Depending on the situation they encounter, microglia may react in a protective manner - engulfing pathogenic organisms, toxins or damaged cells - or release toxic substances that directly destroy microbes or infected brain cells. Since this neurotoxic response can also damage healthy cells, keeping it under control is essential, and excess neurotoxicity is known to contribute to the damage caused by several neurodegenerative disorders.

El Khoury's team set out to define the transcriptome - the complete set of RNA molecules transcribed by a cell - of the microglia of healthy, adult mice and compared that expression profile to those of macrophages from peripheral tissues of the same animals and of whole brain tissue. Using a technique called direct RNA sequencing, which is more accurate than previous methods, they identified a set of genes uniquely expressed in the microglia and measured their expression levels, the first time such a gene expression 'snapshot' has been produced for any mammalian brain cell, the authors note.

Since aging is known to alter gene expression throughout the brain, the researchers then compared the sensome of young adult mice to that of aged mice. They found that - contrary to what previous studies had suggested - the expression of genes involved in potentially neurotoxic actions, such as destroying neurons, was downregulated as animals aged, while the expression of neuroprotective genes involved in sensing and removing pathogens was increased. El Khoury notes that the earlier studies suggesting increased neurotoxicity with aging did not look at the cells' full expression profile and often were done in cultured cells, not in living animals.

"Establishing the sensome of microglia allows us to clearly understand how they interact with and respond to their environment under normal conditions," he explains. "The next step is to see what happens under pathologic conditions. We know that microglia become more neurotoxic as Alzheimer's disease and other neurodegenerative disorders progress, and recent studies have identified two of the microglial sensome genes as contributing to Alzheimer's risk. Our next steps should be defining the sensome of microglia and other brain cells in humans, identifying how the sensome changes in central nervous system disorders, and eventually finding ways to safely manipulate the sensome pharmacologically."

Source: Eurekalert

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Princess Anne Suggests Compatriots to Eat Horsemeat

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Learn Adobe Illustrator CS6 Master Techniques from an Adobe Guru!

With over 25 years of experience teaching, Robert Farrell has been a trusted instructor for individuals and companies who want to improve their Adobe skills.
From our sponsors
Princess Anne Suggests Compatriots to Eat Horsemeat
Nov 16th 2013, 11:09

Known for her love for horses, Princess Anne suggests her compatriots to eat animals like the French.

Queen Elizabeth II's daughter, a former eventing champion, said farming the creatures for their flesh in Britain could improve their welfare.


"Our attitudes to the horsemeat trade and the value of horsemeat may have to change," Anne said in a speech to the World Horse Welfare charity in London on Thursday.

"If that's true then, that they (producers) value their horses, they look after them well, because they're in the horsemeat trade... should we be considering a real market for horsemeat?

"And would that reduce the number of welfare cases if there was a real value in the horsemeat sector? I chuck that out for what it's worth because I think it needs a debate."

Horsemeat consumption is generally taboo in Britain and Anne's comments come just months after a major European scandal involving horsemeat mislabelled as beef.

British newspapers ran headlines about her comments including "Let Them Eat Horse" -- a reference to the executed French queen Marie Antoinette's reported comment "let them eat cake" when asked about the poor.

Anne, who is 11th in line to the British throne, cited France as an example of a country where horsemeat is popular.

"As I was reminded not so long ago by somebody who travelled in France, the most expensive piece of meat in the local butcher was a fillet of horsemeat," she said.

"We've got to face that. We've got to understand whether that value has also a part to play in how we reduce welfare cases."

Source: AFP

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Man Marries Tree in Argentina

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
The Next Generation in Online Meetings

GoTo Webinar is a new, affordable, do-it-yourself Web event service that doesn't require a consultant. Get $10 off after your complimentary trial.
From our sponsors
Man Marries Tree in Argentina
Nov 16th 2013, 11:09

Your comments are automatically posted once they are submitted. All comments are however constantly reviewed for spam and irrelevant material (such as product or personal advertisements, email addresses, telephone numbers and website address). Such insertions do not conform to our policy and 'Terms of Use' and are either deleted or edited and republished.
Please keep your comments brief and relevant.This section may also have questions seeking help. If you have the information you are welcome to respond, but please ensure that the information so provided is genuine and not misleading.

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Scientists Discover New Genetic Cause of Warburg Micro Syndrome

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Retargeting on Facebook?

Get more sales and conversions with Facebook retargeting. Try it free for 14 days. Set up takes just minutes!
From our sponsors
Scientists Discover New Genetic Cause of Warburg Micro Syndrome
Nov 16th 2013, 09:08

Gene responsible for Warburg Micro syndrome, a rare genetic disease characterized by eye, brain and endocrine abnormalities has been discovered by scientists. Patients with Warburg Micro syndrome are severely physically and mentally challenged, unable to learn how to walk or speak and become blind and paralyzed from an early age.

The findings are published in The American Journal of Human Genetics. Lead co-authors are Ryan Liegel, Ph.D., postdoctoral student in cell biology, neurobiology and anatomy at the Medical College of Wisconsin; and Mark Handley, Ph.D., postdoctoral researcher at the University of Edinburgh. Corresponding author is Duska J. Sidjanin, Ph.D., associate professor of cell biology, neurobiology and anatomy and member of the Human and Molecular Genetics Center at the Medical College of Wisconsin.

In this study, the researchers became interested in a gene called TBC1D20, which is known to cause blindness and sterility in mice, because of that similar phenotype. The research team evaluated a cohort of more than 70 families with Warburg Micro syndrome, and found five distinct loss-of-function mutations in TBC1D20, thus establishing those mutations as a cause of the disease.

"These findings have implications not only for families affected with Warburg Micro syndrome, but also provide novel information about the genes and molecular pathways essential for human development that is relevant for more common developmental disorders such as epilepsy and autism," said Dr. Sidjanin.

The four genes do not comprise the full causative picture for Warburg Micro syndrome; in about half of the cases, the causing mutation was in none of those genes, which means there are additional novel genes contributing to the disease.

The researchers plan to continue to search for additional genes, and will also model the disease in tissue cultures with a hope of understanding the underlying molecular and cellular events in which TBC1D20 is involved.

Source: Eurekalert

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Washington's Health Insurance Succeeds as Federal Programs Fail

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Retargeting on Facebook?

Get more sales and conversions with Facebook retargeting. Try it free for 14 days. Set up takes just minutes!
From our sponsors
Washington's Health Insurance Succeeds as Federal Programs Fail
Nov 16th 2013, 08:10

Washington is one of 14 states with its own health insurance marketplace and the sign-up numbers are better here. It ranks 3rd in the number of sign ups, as it has created its own marketplace and does not rely on the federal government.

Some people have a problem signing online but the majority of consumers find it more convenient to sign up online. To date, nearly 660,000 people have visited Washington's health plan finder's website and 77,000 have signed up for insurance. Of those people, roughly 9,000 signed up through private health plans and 68,000 with Medicaid. Better Health Together is run by Curt Fackler an in-person assistance group which helps people enroll in health care through the state's exchange.

"We've been able to solve a lot of problems and answer questions and people really do like that touch," Fackler said. He said roughly 90-percent of those enrolled are single. So how much does the insurance cost? Fackler crunched the numbers and found, for instance, a 30-year-old man living in Spokane and making $25,000 a year could pay $117 a month in one plan. Another plan, with a lower deductible, would cost $167.

You can also shop online without filling out an application."The process is a lot quicker and a lot easier, once you decide what you want, now you can go in and create an application," Fackler said. The state's website has been beset with glitches, by now most of the problems have been resolved. In order to be insured by January 1, you have to sign up and pay by December 23.

If you want to meet someone in person to talk about insurance plans there are a number of places around the area you can go, including some local CHAS clinics and libraries. They've trained 250 employees at those sites to enroll people.

References:

Hannah Punitha (IRDA Licence Number: 2710062)

Kylee Cruz, November 2013

Source: Medindia

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Gut Bacteria Help Improve Mental Health

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Your small business full-time assistant

Join the 500,000+ people using Shoeboxed to streamline accounting and bookkeeping. Turn a pile of receipts into digital data to save time, money and hassle.
From our sponsors
Gut Bacteria Help Improve Mental Health
Nov 16th 2013, 08:10


While many of the numerous health-improvement claims have yet to be supported scientifically, it has been claimed that micro-organisms do exert positive effects in intestinal tracts, particularly when used to counteract the effects of antibiotics, which kill both 'bad' and 'good' bacteria.

Over the past few years, studies have been undertaken to explore the possible impact of probiotics on behaviour. It is within this context that the concept of a psychobiotic has arisen.

Timothy Dinan and his colleagues from University College Cork in Ireland, define a psychobiotic as "a live organism that, when ingested in adequate amounts, produces a health benefit in patients suffering from psychiatric illness."

The gut microbiota, which contains approximately 1 kg of bacteria, can be modulated by diet and many other factors. It is not static and can change from day to day, starting at birth. Evidence has shown that even the form of delivery (vaginal versus cesarean) alters an individual's microbiota.

Dinan and his colleagues review one study that assessed the potential benefits of a specific probiotic, B. infantis, in rats displaying depressive behaviour due to maternal separation. The probiotic treatment normalized both their behaviour and their previously-abnormal immune response.

This preclinical study and others like it strongly support the hypothesis that probiotics have the potential to exert behavioural and immunological effects.

The study is published in Biological Psychiatry.

Source: ANI

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Democrats Vote Against the Affordable Care Act in the Matter of Cancellation of Policies

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Want to speak effortlessly in any situation?

Actress Alexa Fisher will teach you tips that will set you on the road to success.
From our sponsors
Democrats Vote Against the Affordable Care Act in the Matter of Cancellation of Policies
Nov 16th 2013, 08:10


The Republican bill was passed which would allow companies to continue selling policies not compliant with the Affordable Care Act Standards. The vote taken to allow companies to sell non-compliant plans included 39 democrats. The voting for Keep Your Health Plan Act was sponsored by Rep. Fred Upton.

Insurance executives and President Obama were joined by Marilyn Tavernner, administrator for the Centers for Medicare and Medicaid Services, and White House Chief of Staff Denis McDonough. "I want to welcome the executives who are here from a lot of the insurance companies that are participating in the marketplace," the president said. "We all share a similar value, which is we want to make sure that Americans have good, solid coverage that gives them the security they need for themselves and their family members if and when they get sick."

According to Upton this move would fulfill a promise Obama had made to the American people and then broke. "In the last three years," Upton said during floor debate, "the president personally promised that if people liked their current healthcare plan, they could keep it 'no matter what.' But cancellation notices are now arriving in millions of mailboxes across the country. It's cancellation today, sticker shock tomorrow."

President Obama said he would veto Upton's bill if it reached his desk. The proposal is about much more that what Obama agreed to, which would only allow insurers and state insurance commissioners to extend those policies through most of 2014 to current policyholders. It was also necessary to inform customers that the Affordable Care Benefits were not included and they would get better benefits while shopping in the health insurance marketplace.

Many Democrats face tough re-election are trying to remedy the cancellation of policies and make Obama keep his promise. "This bill is not a bill to let people keep their health insurance plans. The president took care of that issue yesterday," Rep. Henry Waxman, D-Calif., said during floor debate Friday. "What this bill is, another vote to repeal the Affordable Care Act."

"We knew this was a promise, Obama could not keep, and now it is a promise he has broken," House Majority Leader Eric Cantor, R-Va., said. The legislation's outlook is unclear in the Senate, where Democrats also up for re-election next year are looking for a way to help consumers who face not having insurance because their policies don't meet requirements of the 2010 law. Sen. Mary Landrieu, D-La., offered her own plan, which would allow people to keep their current plans indefinitely. However, after the president's announcement Thursday, many Senate Democrats said they would wait to see if additional legislation was necessary.

References:

Hannah Punitha (IRDA Licence Number: 2710062)

Top News, November 2013

Source: Medindia

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Friday, November 15, 2013

Interesting Facts about the Human Heart

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Retargeting on Facebook?

Get more sales and conversions with Facebook retargeting. Try it free for 14 days. Set up takes just minutes!
From our sponsors
Interesting Facts about the Human Heart
Nov 16th 2013, 07:08

Your heart is probably the most important organ of your body; and why not? Considering its remarkable ability to keep the body going, and the various organs and organ systems functioning normally, it does deserve all the extra care and attention.

But do you know all about this 'most important' part of your body? Here are some really cool facts about the heart that you probably didn't know-

Size issues: The size of the heart can be estimated by looking at the fist-for kids, the heart is around the same size as one fist, and for adults it is two.

It beats: In a day, the heart beats for more than 100,000 times; and in a whole lifetime, it can go as high as 2.5 billion beats.

Pump it up: Your heart pumps out a lot of blood in the entire lifetime-by a lot, we mean approximately equal to 3 super tankers.

Time factors: A normal kitchen faucet would need to be running for at least 45 years to flow out the same amount of water as the blood pumps out during an average lifetime.

Electric it is! The heart has a power output ranging from 1-5 watts; calculated for 80 years, it equals around 2.5 gigajoules of power.

Super cell: The human body contains over 75 trillion cells, and all of them have access to the blood pumped by the heart; except for the cornea of the eye.

Lub dub: The heart contains 4 valves, and the lub dub sound of the heart beating is actually made by the closing and opening of the valves of the heart.

Beats 4 you: The heart of a baby begins at around 4 weeks after conception.

Tissue or liquid: As much as it looks like a reddish blue liquid, blood is actually a tissue, just like your skin, kidney and many other parts of the body.

Speed it up: When you are at rest, it takes just six seconds for your blood to get from your heart to your lungs, and back; and about eight seconds for it to travel from the heart to the brain and back; and just sixteen seconds for it to travel from the heart to the toes and back to the heart.

Men-women: A woman's heart beats much faster than a man's on an average- it beats for around 78 times a minute, while a man's heart beats around 70 times per minute.

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

New Technique for Developing Drugs to Treat Serious Illnesses Identified

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Retargeting on Facebook?

Get more sales and conversions with Facebook retargeting. Try it free for 14 days. Set up takes just minutes!
From our sponsors
New Technique for Developing Drugs to Treat Serious Illnesses Identified
Nov 16th 2013, 07:08


Researchers in the Department of Cardiovascular Sciences and Department of Biochemistry at the University of Leicester, together with colleagues in Cambridge, the USA and Italy, have employed a new technique to create protein-based drugs.

According to Professor Nick Brindle, the lead researcher: "This technique harnesses the power of evolution to engineer specific functions into a protein, such as the ability to neutralise a toxin or to activate healing.

"This involves making a particular cell type generate millions of different variants of our protein, selecting the variants that have improved properties and then repeating the cycle until the protein has been changed to a form with the exact properties we want."

To show how the method works, the group took a protein normally found in the body and evolved it into a form that can block a molecule involved in blood vessel growth and inflammation.

This new protein, called a ligand-trap, is now being developed as a potential therapeutic for treating heart disease, inflammation and other illnesses.

Said Professor Brindle: "The idea that you can evolve proteins into forms that do what you want is not new, but it has been very difficult to do this for many of the complex proteins that we want to use as drugs or for other applications.

"This new approach promises to make engineering of such proteins not only possible but relatively easy. In addition to medicine, these specifically evolved 'designer proteins' have a wide range of applications in the chemical, pharmaceutical, and agricultural industries.

"This is a big step forward. We are hoping that, over the next five years or so, this new protein can be developed into a form that could be used to treat inflammation and other conditions."

The work, being published in the Journal of Biological Chemistry, was funded by the Biotechnology and Biological Sciences Research Council (BBSRC), MRC and the Wellcome Trust. The Leicester team collaborated principally with Dr Julian Sale at the MRC Laboratory of Molecular Biology in Cambridge, with additional input from Dr Hiroshi Arakawa in Italy and Dr Jean-Marie Buerstedde at Yale.

Professor Brindle said: "We are really excited about getting this technique to work and are already using it to make other new molecules that we think will be useful to people. It was a real bonus for us to be able to evolve the ligand trap using the technique as this trap targets a molecule that is involved in a whole range of health problems."

Source: Eurekalert

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions

Sandoz's TB Combination Drug 4D and 4D Plus Recalled Due to Inappropriate Dosage on the Strips

Medindia Health News
Medindia largest health website in india. // via fulltextrssfeed.com 
Economist GMAT Tutor.

The results you want. The flexibility you need. Claim your 7-day free trial today.
From our sponsors
Sandoz's TB Combination Drug 4D and 4D Plus Recalled Due to Inappropriate Dosage on the Strips
Nov 16th 2013, 06:09

The Maharashtra FDA received reports that strips of pharma major, Sandoz's TB combination drug, 4D, sold across six states carried the wrong dosage.

On investigation, FDA inspectors found that a more powerful version of the TB drug called 4D plus also carried the wrong dosage. The FDA has ordered the suspension of the sale of drugs 4D and 4D Plus in the state and also alerted the other states where the drug is marketed.

This information to the FDA in Maharashtra was passed on by a South Mumbai Doctor who had noticed the wrong dosage on some strips that one of his patients had bought from a pharmacy in Cumballa Hill.

The patient had come to him after falling extremely sick with bouts of vomiting as he had consumed five such strips.

Consuming drugs in wrong dosages is extremely dangerous. Not only does it render the drug ineffective, such inappropriate dosages can be one of the reasons for the TB bacterium developing great resistance to antibiotics.

Source: Medindia

You are receiving this email because you subscribed to this feed at blogtrottr.com.

If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions