X-linked MeCP2 is a New Target for Treating Parkinson's Disease

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X-linked MeCP2 is a New Target for Treating Parkinson's Disease Aug 13th 2013, 18:37 Prof. Xianhou Yuan and team from Zhongnan Hospital of Wuhan University used 6-hydroxydopamine-induced human neuroblastoma cell (SH-SY5Y cells) injury as a cell model of Parkinson's disease. The researchers found that overexpression of X-linked methyl-CpG binding protein 2 was able to ameliorate the effects of 6-hydroxydopamine, it reduced 6-hydroxydopamine-induced apoptosis, and increased the levels of tyrosine hydroxylase in SH-SY5Y cells. These findings, published in the Neural Regeneration Research (Vol. 8, No. 21, 2013), suggesting that X-linked methyl-CpG binding protein 2 may be a potential therapeutic target for the treatment of Parkinson's disease. Source-Eurekalert

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