Study Reveals That Treatment Of Severe Alcoholic Hepatitis Using Combination Therapy Does Not Result in Improved Survival

Medindia Health News Medindia largest health website in india. // via fulltextrssfeed.com

Learn Adobe Illustrator CS6 Master Techniques from an Adobe Guru! With over 25 years of experience teaching, Robert Farrell has been a trusted instructor for individuals and companies who want to improve their Adobe skills. From our sponsors

Study Reveals That Treatment Of Severe Alcoholic Hepatitis Using Combination Therapy Does Not Result in Improved Survival Sep 15th 2013, 06:39 Treatment of severe forms of alcoholic hepatitis is extremely challenging because of the poor outcome. European and U.S. guidelines recommend the use of prednisolone or pentoxifylline in patients with severe alcoholic hepatitis. Nevertheless, a substantial proportion of patients die after 6 months regardless of first-line therapy, according to background information in the article. Philippe Mathurin, M.D., of the Hopital Hurlez, Lille, France and colleagues compared the efficacy of a combination of prednisolone and pentoxifylline with prednisolone alone in patients with severe alcoholic hepatitis in 1 Belgian and 23 French hospitals. Duration of follow-up was 6 months. They randomly assigned 270 patients (18 to 70 years of age, who were heavy drinkers with severe biopsy-proven alcoholic hepatitis) to receive 40 mg of prednisolone once a day and 400 mg of pentoxifylline 3 times a day (n=133) for 28 days, or 40 mg of prednisolone and matching placebo (n=137) for 28 days, between December 2007 and March 2010 Eighty-two deaths occurred in the 2 groups during the 6-month follow-up, due to complications from liver failure in 67 cases (81.7 percent) and other causes including gastrointestinal bleeding in 15 cases (18.3 percent). The researchers found no difference in 6-month survival between the 2 groups (69.9 percent in the pentoxifylline-prednisolone group [40 deaths] vs. 69.2 percent [in the placebo-prednisolone group [42 deaths]). Response to treatment and the probability of being a responder were also no different between groups. The cumulative incidence of hepatorenal syndrome (rapid deterioration in kidney function) at 6 months was also not different in the pentoxifylline-prednisolone and the placebo-prednisolone groups. Because of the lack of difference in survival and other outcomes, "our study does not support the use of a combination of pentoxifylline and prednisolone for severe alcoholic hepatitis," the authors write, concluding that "future studies with an appropriate design are needed to provide robust data for developing new strategies to improve the outcome of patients with this life-threatening disease." Source-Newswise

You are receiving this email because you subscribed to this feed at blogtrottr.com. If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions